Protagonists in isekai anime are guaranteed to get their lives either cut short or interrupted. These characters either die and get the opportunity to reincarnate in another world, or they get sent to a fantasy world either through transportation or summoning by a mage or someone of authority. However, most protagonists get compensated for the interruption or inconvenience by receiving extraordinary abilities or skills from ‘God’ that give them an advantage in this new world.
As they journey through their new world, facing many challenges along the way, these blessings, abilities, and powers help them navigate, especially if there are monsters involved. These blessings overpower the protagonist, meaning he or she is the strongest in their new world, and others, monsters or humans in this new world, cannot easily defeat them.
Updated June 29, 2025, by Oluwatokiloba Folami:In the world of Isekai, be it manga or anime, ordinary individuals get whisked away to fantastical worlds. This usually takes place either through summoning or reincarnation, to carry out a specific mission or to just live their life. However, some protagonists are luckier than others. They receive blessings so powerful that they break the power scale, making them overpowered, and a force in this world. These God-given powers often grant the protagonists unparalleled abilities, making them formidable forces in their new realms. From extraordinary combat skills and magical prowess to unique talents that defy the laws of their new world, these blessings set the stage for epic adventures and intense battles.
Problem Children Are Coming from Another World, Aren’t They?
Azuka’s life changes when she receives a mysterious letter that transports her and her friends, Izayoi and Yo, to Little Garden. Here, they have extraordinary abilities and spend their time playing games to attain wealth for their committee. These three kids lived extremely average and uninteresting lives before this encounter. Now in this new world, they are determined to help the No Name community regain their status.
This ability is something that Azuka was born with, and it is believed that the Japanese gods gave it to her. This ability is called Oraculum, and it gives herverbal authority over living and non-living things.
I’ve Been Killing Slimes For 300 Years And Maxed Out My Level
Most isekai protagonists are Japanese citizens who, for some unfortunate reason, die before their time.The main protagonist of this anime, Azusa Aizawa, was a Japanese salary woman who died from overworking and lack of rest. Now in an alternate world where magic exists, she becomes Azusa and is determined to spend her time relaxing and doing little to nothing, and that means killing slimes.
Being immortal is the only reason why Azusa has been able to kill slimes for over 300 years. This gift was granted to her by Goodly godly goddess, the goddess who reincarnated her into this new world.
The Aristocrat’s Otherworldly Adventure: Serving Gods Who Go Too Far
Kazuyatakes on more than he can handle when he tries to be a hero by protecting two young girls from an attacker armed with a knife. Things go wrongwhen the attacker stabs him, and he ends up dyingfrom his wounds. However, because of this selfless act, Kauzya reincarnates as Cain, a young boy from a noble family. Cain discovers that he is in a world filled with magic and adventure, and he cannot wait to take part. He quickly starts learning magic and how to read, but he is still too young to practice anything.
Cain comes in front of the seven gods during his trip to the church with his parents and sister. Kazuya’s good deed greatly impressed the gods. Despite finding out that his death was unnecessary and that his memories came to him too early, Cain is still very optimistic and accepts his new fate. This makes the gods even like him more, and each of them bestows their power on him, making him incredibly overpowered in his new world.
6Immeasurable Magical Powers
Reiji Saeki
Reijidies after getting involved in a bicycle accident, but instead of dying, he finds himself in the presence of a magician looking for an heir. This magician decides to choose Reiji, and he reincarnates into the magician’s magical world, equipped with all their abilities and knowledge.
Reiji has a list of abilities that he got from the magician, like healing magic, regeneration, eternal youth, and more, but what makes him stand out are the magical powers he inherited. His magical powers, also given to him by the magician, give him an enormous headstart in this world and also put him at an advantage against magical and non-magical creatures.
Adele Von Ascham
Didn’t I Say To Make My Abilities Average In The Next Life?!
Didn’t I Say to Make My Abilities Average in the Next Life?! is an anime series based on the light novel by FUNA. It follows the story of Kurihara Misato, who is reincarnated with extraordinary powers despite her wish to be average, leading her to navigate a new world filled with adventures and friendships.
‘No one likes a nerd’ might be a popular statement, and it sums accurately up Misato’s life before she died. Misato was a genius, at the top of her class, and this status intimidated other students and kept them away from her. Up until graduation, Misato had no friends, and unfortunately, she died that way. She was killed while saving a girl, and this good deed gave her the opportunity to be reincarnated.
After suffering a lonely and isolated life, Misato desperately wished to be average, but this little genius was not aware that people had different definitions of what they considered average. In this new world she is reborn asAdele, and she is far from average. This “average ability” that God gives her is a package deal, and it comes with increased physical strength, senses, vision,and so much more, and thus still making her extremely overpowered in her new world.
4Invulnerability
Mary
The protagonist of this manga is a sick young girl on her deathbed. She had been sick all her life, and her only wish while dying was to have a strong and healthy body that could not succumb to diseases or sickness. This young girl dies and is reborn asMary Regalia. Not only is she healthy, but she is incredibly strong. Mary’s body is maxed out in every sense and is prepared for any type of attack, especially magic attacks.
Being blessed with invulnerability means that Mary is immune to any type of harm and that she cannot suffer physical damage. In a world of magic, adventure, and monsters, this ability is the ultimate cheat, as no one can possibly defeat Mary. Meanwhile, she can enjoy having her wish from her previous life granted.
Rimuru Tempest
That Time I Got Reincarnated as a Slime
Based on Fuse’s novel and light novel series, That Time I Got Reincarnated as a Slime is an isekai anime that follows Rimuru, a guy who reincarnates in a fantasy world as its weakest monster. However, that soon changes.
Reincarnating as a slimeis not something a protagonist hopes for or wants; however,Rimuru Tempesthappens to be the most powerful slime in his new fantasy world.Rimuru has a long list of powers, but none would be possible without his predation ability. This ability allows Rimuru to absorb his opponent as well as their powers, which lets him gain powers and level up.
Rimuru might look weak as a slime, but this special ability of his is the reason he has been able to gain more powers. The moment he comes across an enemy, if all else fails, Rimuru can depend on his Predation to instantly absorb the opponent in front of him and end the ‘battle.’
2Skill-Take Ability
Konoe Yuuto
Konoe Yuutofinds himself in another world after some orcs summon him. He tries to find his way back home but to no avail, and soon, he discovers that he has a special ability that makes him overpowered in this new world.
This skill-taking abilityKonoe possesses causes him to steal the unique skills and abilities of the monsters or people he defeats. He uses his ability on the orcs that summoned him to this world, stealing their powers and killing them afterward. With this ability, he is able to rack up an impressive amount of skills and powers from his opponents, making him essentially as powerful as the strongest foe he ever faces.
My Instant Death Ability is So Overpowered, No One in This Other World Stands a Chance Against Me!
Takatouenjoys playing video games and sleeping.He is calm and laid back, and his special ability seems to suit his personality. Takatou finds himself in a fantasy world after a mage summons him and his classmates to defeat the Demon King and his armies. This mage bestows upon them all special abilities, but Takatou seems to be the luckiest of them all with the powerful and convenient ability he receives.
In this series, Takatou has an instant death ability, which instantly invokes death. All Takatou has to do is think about his opponent or enemies dying, and they die instantly. Sometimes he accompanies his thoughts with the phrase “die,” but it is not necessary, as just the mere thought is enough to kill his opponents. Instant Death Ability gives him the ultimate upper hand against his enemies, as he does not even have to get into a fight with them, and even better, distance is not a problem, as he can kill someone miles away from him.
In the manga and light novel, Takatou gets his powers from a unique source that is something akin to a deity, while technically not being a god. That said, they are similar enough to warrant a mention.
