Mewtwois typically considered to be one of the most powerful creatures in thePokemoncanon universe. And, though that is a truly bold statement, it is also a factual one. Very few creatures are powerful enough to go toe-to-toe with Mewtwo and very few are dim-witted enough to try it.
Related:Pokemon Unite: Legendary Pokemon They Should Add In The Game
Mewtwo is an incredibly powerfulPokemonthat was genetically engineered to be a fighting machine. This makes it an all-around tank that cannot easily be taken down. However, there are a few creatures that can hold their own againstMewtwo. Though they might not be able to defeatMewtwooutright, they will still provide enough of a challenge to keep things interesting and make it a rather equal match.
Updated on June 05, 2025 by Ben Painter:Mewtwo stands out asone of the most iconic Pokemon in the franchise, making its anime debut inPokemon: The First Movie. It is iconic for 90s kids and the Pokemon brings a wave of nostalgia to many fans. The psychic-type legendary Pokemon has stood the test of time, and it still stands out as one of the most powerful Pokemon in the games.
Throughout each generation, there have been new suitors to take up the mantle of a worthy battle opponent forMewtwobut very few have managed to live up to the task. But with the release ofPokemon Scarlet & Violetin late 2022, came with new Pokemon for gamers to collect and use in battle. There are a few of these that can even best the mightyMewtwoin a battle.
23Gengar
Gengar might not be as rare or powerful as a legendaryPokemon, but itcan certainly put up a good fightagainst Mewtwo. These two Gen 1 powerhouses have remained some of the strongest of their type since first being introduced, receiving various forms and tweaks along the way.
Type weaknesses affect bothPokemonnegatively here, putting them on a level playing field. Though Mewtwo gets the slight edge in Speed, Gengar has a versatile learnset that could prove to be the deciding force in a confrontation between the two.
22Deoxys
This would be a battle between two Psychic-type heavyweights. Both Deoxys andMewtwobring a lot to the table, but Deoxys has the Gen 1 icon outmatched in its versatility.
Related:New Exeggutor-Themed Pokemon Jet Will Start Flying Around Japan Soon
Its four different forms let it capitalize on different stats, giving it the ability to gauge the battle and adjust when necessary. Its regenerative abilities provide it with a massive advantage that evenPokemonas strong as Mewtwo would have a tough time dealing with.
21Eternatus
Introduced to the franchise inPokemon Sword & Shield, Eternatus stands as an intimidating foe for any challenger. The Poison/Dragon-type outsizes Mewtwo quite a bit, ensuring an uphill battle for the Gen 1 Psychic-type.
Eternamax Eternatusis even bigger, completely overshadowingMewtwo. Its signature move, Eternabeam, is an incredibly powerful attack that even Mewtwo would have trouble defending against. Though it might be an interesting match-up, Mewtwo could very well be outmatched.
20Jirachi
It might not look the part, but Jirachi makes for a formidable foe in battle. The mythical Psychic/Steel-type has a peculiar ability that makes it difficult for anyPokemonto plan for during a fight.
Related:All the Pokemon Misty Catches in the Anime
With its wish-making ability, Jirachi is a true wild card that boasts a potentially game-changing power. It fares well against Psychic-types, which should give it a decent chance at bestingMewtwo.
19Yveltal/Xerneas
Mewtwo has tons of potential in its stats and movepool. However, in terms of what can match it, bulkierPokemonthat resist its variety of STAB attacks give it a run for its money. The best for this are bulky psychic types andbulky fairy types. Dark types can also negate a lot of what Mewtwo can do offensively. TwoPokemonthat fulfill all of these requirements are Yveltal and Xerneas, the box legendaries from Gen 6.
Both of theselegendary Pokemonpack high offensive stats and HP, allowing them to bust through Mewtwo’s sizable bulk. Moreover, they can each checkMewtwothat don’t come equipped to handle them. Yveltal, although it needs to be wary of Ice Beam, can easily dispatch it with powerful dark-type attacks. Xerneas can easily checkMewtwowith its sizable bulk and even setup to become even more powerful. These would easily dispatchMewtwo.
18Aegislash
The blade, the myth, the legend that is Aegislash is anotherPokemonthat can matchMewtwo. Manyghost typescreate problems forMewtwo, as they exploit one of its biggest weaknesses. In some cases, Aegislash can completely wall outMewtwothat don’t have Fire Blast, Shadow Ball, or Earthquake. Shield-form Aegislash can take a ton of powerful hits even from this legendary beast.
Moreover, Aegislash’s sword form can demolishMewtwowith ease. Powerful priority moves like Shadow Sneak give Aegislash the ability to deal serious damage, and it boasts other powerful attacks to fill in the rest of its weaknesses. With excellent offense and defense, Aegislash is the perfect weapon to fight a godlike entity like Mewtwo. It earned its title of “Smogon Sword” for a good reason, after all.
17Mega Sableye
Mega Evolutions, although they currently lay dormant inScarlet & Violet, are a serious threat in many situations. Mega Gengar, for example, could make quick work ofMewtwowithout a second thought. However, sometimes the best offense is a good defense, and a good defense can lead to annoying the opponent into submission. FewPokemonare as capable of doing that as Mega Sableye.
Sableye in its regular form isn’t much to look at. Its Mega Evolution allows it to disarm status moves with Magic Bounce, then proceed to burn and Knock-Off the competition.Mewtwoin any of its forms can hardly dent this brilliant gemPokemon, and its typing walls all of Mewtwo’s potential stab attacks completely. If there was ever aPokemonto makeMewtwouseless, Mega Sableye is the right option.
16Alolan Muk
Mega Evolutions and obviously powerful regularPokemonare obviously going to keepMewtwoin check, that much is certain. So, how about an under-usedPokemon, brought from the trenches specifically to check and threaten legendary psychic types? Enter Alolan Muk: a serious competitive threat. This multicolored sludge, despite its weaknesses, has the rightdark typingand moveset to keep many powerful legendaries in check.
Related:Pokémon: Pokémon That Should Be Legendary But Aren’t
Alolan Muk’s biggest boon is its ability to use Pursuit and trapMewtwoin battle. If anotherPokemoncan weakenMewtwo, Alolan Muk will always be able to finish the job. Of course, inScarlet & Violet,Pokemonaren’t legally allowed to use Pursuit as a technique. Does this make Alolan Muk useless? Absolutely not, since it still has solid bulk and typing to survive an attack and retaliate with force.Mewtwoshould be afraid of this sludge, despite its sweet smell.
15Klefki
Legendaries can challengeMewtwo. Gigantamax and Mega Evolutions can obviously challengeMewtwoas well. Even a couple of regularPokemonthat have promise in high levels of play can take downMewtwo. But, like Mega Sableye, how about testingMewtwo’s patience with one of the most obnoxious and bulky fairy types in the game? That’s right, Klefki is the real secret toMewtwo’s destruction.
Klefki’s ability, Prankster, always gives it priority with status moves. This allows it to paralyzeMewtwofor free, giving it room to set up hazards, confusion, or even attempt to fightMewtwohead-on with Foul Play. Sure, ifMewtwocan execute a move to actually hit Klefki, it might not survive, but it has to be able to move first. With enough luck, they can definitely take down aPokemonconsidered one of the most powerful in thePokemonworld.
14Mew
There’s certainly an argument to be made that themythical PokemonMew can take downMewtwo.Mewtwois a simple clone of Mew. Mew holds the DNA of everyPokemon, and can learn every single move in existence. This is something that its clone cannot do.
Related:All the Fossil Pokemon in the Franchise So Far
Mew is the basis forMewtwo’s entire existence.Red and Blueeven hints that Mew gave birth toMewtwo. If there’s anyone who can take downMewtwo, who better to do it than its genderless parent? It only makes sense.
